The Toronto-bound QEW will be closed for several hours at the Burlington Skyway due to a multi-vehicle crash.
The OPP said it happened around 6:15 a.m. on Monday.
The multi-vehicle crash involved a transport truck, as well as a motorcycle.
Police said the rider of the motorcycle was pronounced dead at the scene.
No further details have been released.
All traffic is being rerouted to Eastport Drive.